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Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats.


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タイトル: Selective upregulation of p66-Shc gene expression in the liver and brain of aged rats.
著者: Sone, Kiyoaki / Mori, Mari / Mori, Nozomu
発行日: 2011年11月28日
出版者: Elsevier Science Ireland
引用: Archives of Gerontology and Geriatrics, 55(3), pp. 744-748; 2012
抄録: The phosphotyrosine signaling followed by various receptor activations conforms a unique signaling platform during metazoan evolution, and is crucial for animal development, maturation, and aging. Shc is the most versatile bipartite phosphotyrosine signal adaptor harboring phosphotrosine-biding (PTB) and Src-homology2 (SH2) domains. Among the Shc adaptor family members, p66-Shc is of potential interest in aging studies, since its deletion in mice resulted in a longer lifespan and/or higher quality of life in later stages of life. However, a few studies have examined the gene expression profiles of p66-Shc in aging tissues. Here, we quantified the expression levels of transcripts of Shc-related isoforms in the liver and brain of young adult, middle-aged, and aged rats, and found that p66-Shc gene expression is specifically up-regulated in the aged liver and brain. In the aged liver tissue, p66-Shc expression was also evident at the protein level, and accumulated in the soluble fraction of the aged tissue. These results indicate that p66-Shc is not only related to animal longevity but also affected during aging, and thus the repression of p66-Shc could become a potential target for an anti-aging strategy.
キーワード: Adapter / Anti-aging / Longevity / Phosphotyrosine / Signal transduction
URI: http://hdl.handle.net/10069/26933
ISSN: 01674943
DOI: 10.1016/j.archger.2011.11.001
PubMed ID: 22130185
権利: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/26933

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