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Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection


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Title: Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection
Authors: Kosai, Kosuke / Seki, Masafumi / Tanaka, Akitaka / Morinaga, Yoshitomo / Imamura, Yoshifumi / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Tomono, Kazunori / Kohno, Shigeru
Issue Date: 2011
Publisher: National Institute of Infectious Diseases / 国立感染症研究所
Citation: Japanese Journal of Infectious Diseases, 64(6), pp.451-457; 2011
Abstract: The mechanisms of severe pneumonia caused by co-infection of bacteria and influenza A virus (IAV) have not been fully elucidated. We examined apoptosis and inflammatory responses in a murine model for pneumococcal pneumonia during IAV infection. Inflammation, respiratory epithelium apoptosis, and inflammatory-cell infiltration increased in a time dependent manner in the lungs of mice co-infected with Streptococcus pneumoniae and IAV, in comparison with those infected with either S. pneumoniae or IAV. According to appearance of terminal deoxynucleotidyl transferase dUTPmediated nick-end labeling positive cells, caspase-3 and -8 were activated 24 h after S. pneumoniae infection, and caspase-3 activation decreased after 48 h, whereas inflammatory cytokine levels continued to increase in co-infected mice. In contrast, in mice infected with either IAV or S. pneumoniae, apoptosis and activation of factors related to caspase-3 peaked at 48 h. Furthermore, Fas-associated death domain was significantly expressed in the lungs of co-infected mice 24 h after S. pneumoniae infection. These data suggest that early onset of apoptosis and its related factors play important roles in fulminant pneumonia resulting from bacterial pneumonia complicated by co-infection with influenza virus.
URI: http://hdl.handle.net/10069/27108
ISSN: 13446304
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27108

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