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Randomized phase II trial of irinotecan with paclitaxel or gemcitabine for non-small cell lung cancer: association of UGT1A1*6 and UGT1A1*27 with severe neutropenia.


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Title: Randomized phase II trial of irinotecan with paclitaxel or gemcitabine for non-small cell lung cancer: association of UGT1A1*6 and UGT1A1*27 with severe neutropenia.
Authors: Nakamura, Yoichi / Soda, Hiroshi / Oka, Mikio / Kinoshita, Akitoshi / Fukuda, Minoru / Fukuda, Masaaki / Takatani, Hiroshi / Nagashima, Seiji / Soejima, Yoshifumi / Kasai, Takashi / Nakatomi, Katsumi / Masuda, Noriyuki / Tsukamoto, Kazuhiro / Kohno, Shigeru
Issue Date: Jan-2011
Publisher: Lippincott Williams & Wilkins Ltd.
Citation: Journal of Thoracic Oncology, 6(1), pp.121-127; 2011
Abstract: Irinotecan-containing regimens are known to be active and tolerable in patients with non-small cell lung cancer (NSCLC). A randomized phase II trial was conducted to evaluate the efficacy of irinotecan plus paclitaxel or gemcitabine for previously untreated stage IIIB or stage IV NSCLC.
Keywords: Gemcitabine / Irinotecan / NSCLC / Paclitaxel / UGT1A1*27 / UGT1A1*6
URI: http://hdl.handle.net/10069/27360
ISSN: 15561380
DOI: 10.1097/JTO.0b013e318200e4e8
PubMed ID: 21150467
Rights: Copyright © 2010 by the international Association fot the Study of lung Cancer. / This is a non-final version of an article published in final form in Journal of thoracic oncology, 6(1), pp.121-127; 2011.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27360

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