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Prevalence of type 2 diabetes mellitus in Japanese patients with hepatocellular carcinoma


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Title: Prevalence of type 2 diabetes mellitus in Japanese patients with hepatocellular carcinoma
Authors: Taura, Naota / Ichikawa, Tatsuki / Miyaaki, Hisamitsu / Yatsuhashi, Hiroshi / Ishibashi, Hiromi / Nakao, Kazuhiko
Issue Date: Jan-2011
Publisher: Spandidos Publications
Citation: Experimental and Therapeutic Medicine, 2(1), pp.81-84; 2011
Abstract: The possibility has been raised in a number of cohort and case-control studies that diabetes mellitus (DM) may increase the risk of liver cancer, as well as that of cancer at other sites. To verify this possibility, we conducted a retrospective cohort study to determine the prevalence of type 2 DM in Japanese patients with hepatocellular carcinoma (HCC). Atotal of 1,251 patients with HCC, diagnosed at two major liver centers in the Nagasaki area, were consecutively recruited and categorized according to the etiology of HCC into four groups: HCC-B, HCC-C, HCC-BC and HCC-nonBC cases. Type 2 DM was diagnosed on the basis of standard criteria. The prevalence rate of HCC-nonBC and HCC-C was significantly higher than that of HCC-B, while the prevalence rate of HCC-nonBC was significantly higher than that of HCC-C. The prevalence of type 2 DM in HCC-B, HCC-Cand HCC-nonBC patients under 66 years of age was 11, 31 and 32%, respectively, vs. 24, 22 and 40%, respectively, in patients over 66 years of age. In patients over 66 years of age, the prevalence of type 2 DM in HCC-B and HCC-nonBC cases was increased, whereas the prevalence of type 2 DMin HCC-C cases was significantly decreased. Our findings indicate that the effects of the interaction between type 2 DM and HCV increase the prevalence of HCC.
Keywords: Diabetes mellitus / Hepatitis virus / Hepatocellular carcinoma
URI: http://hdl.handle.net/10069/27362
ISSN: 17920981
DOI: 10.3892/etm.2010.167
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27362

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