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Antifungal Susceptibilities of Aspergillus fumigatus Clinical Isolates Obtained in Nagasaki, Japan


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Title: Antifungal Susceptibilities of Aspergillus fumigatus Clinical Isolates Obtained in Nagasaki, Japan
Authors: Tashiro, Masato / Izumikawa, Koichi / Minematsu, Asuka / Hirano, Katsuji / Iwanaga, Naoki / Ide, Shotaro / Mihara, Tomo / Hosogaya, Naoki / Takazono, Takahiro / Morinaga, Yoshitomo / Nakamura, Shigeki / Kurihara, Shintaro / Imamura, Yoshifumi / Miyazaki, Taiga / Nishino, Tomoya / Tsukamoto, Misuzu / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Yoshihiro / Yasuoka, Akira / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: Jan-2012
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy, 56(1), pp.584-587; 2012
Abstract: We investigated the triazole, amphotericin B, and micafungin susceptibilities of 196 A. fumigatus clinical isolates in Nagasaki, Japan. The percentages of non-wild-type (non-WT) isolates for which MICs of itraconazole, posaconazole, and voriconazole were above the ECV were 7.1%, 2.6%, and 4.1%, respectively. A G54 mutation in cyp51A was detected in 64.2% (9/14 isolates) and 100% (5/5 isolates) of non-WT isolates for itraconazole and posaconazole, respectively. Amphotericin B MICs of ≥2 μg/ml and micafungin minimum effective concentrations (MECs) of ≥16 μg/ml were recorded for two and one isolates, respectively.
Keywords: Aspergillus fumigatus / susceptibility / Japan
URI: http://hdl.handle.net/10069/27382
ISSN: 00664804
DOI: 10.1128/AAC.05394-11
Rights: Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27382

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