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In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.


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Title: In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.
Authors: Araki, Nobuko / Yanagihara, Katsunori / Morinaga, Yoshitomo / Yamada, Koichi / Yamada, Yasuaki / Kohno, Shigeru / Kamihira, Shimeru
Issue Date: Jun-2011
Publisher: Springer
Citation: Journal of infection and chemotherapy, 17(3), pp.318-321; 2011
Abstract: Doripenem is a carbapenem antibiotic with broad-spectrum coverage of gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa, and is considered to be as effective as meropenem. The in vivo activity of doripenem was thus compared with that of meropenem in a chronic lower respiratory P. aeruginosa infection mouse model. The number of viable bacteria in the lungs of mice after treatment with doripenem, meropenem, and saline was 2.01 ± 0.69, 2.03 ± 0.48, and 3.90 ± 1.40 log(10) CFU/lung, respectively. The number of viable bacteria in the lungs of mice treated with doripenem and meropenem was significantly lower than that in lungs of controls. Histopathological examination of lung specimens from the control group revealed promotion of the inflammatory response in chronic bronchial infection. However, the groups treated with doripenem and meropenem showed weaker inflammatory responses. These results suggest that doripenem treatment is effective against chronic airway infection with P. aeruginosa.
Keywords: Carbapenem / Chronic respiratory infection / Doripenem / Lung / Mouse model / Pseudomonas aeruginosa
URI: http://hdl.handle.net/10069/27410
ISSN: 1341321X
DOI: 10.1007/s10156-010-0166-1
PubMed ID: 20972597
Rights: © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2010 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27410

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