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Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells.

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Title: Aberrant overexpression of membrane-associated mucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells.
Authors: Hasegawa, Hiroo / Komoda, Minori / Yamada, Yasuaki / Yonezawa, Suguru / Tsutsumida, Hideaki / Nagai, Kazuhiro / Atogami, Sunao / Tsuruda, Kazuto / Osaka, Akemi / Sasaki, Daisuke / Yanagihara, Katsunori / Imaizumi, Yoshitaka / Tsukasaki, Kunihiro / Miyazaki, Yasushi / Kamihira, Shimeru
Issue Date: Jun-2011
Publisher: Informa UK
Citation: Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011
Abstract: Aberrant overexpression of membrane-associated mucin (MUC1) is implicated in the pathogenesis of cancer, particularly of adenocarcinomas. Adult T-cell leukemia/lymphoma (ATL), an aggressive neoplasm etiologically associated with human T-lymphotropic virus type-1 (HTLV-1), exhibits invasive tropism into various organs, resulting in disease progression and resistance to treatment. In the present study, we showed that MUC1 is overexpressed exclusively in cells of ATL among hematological malignancies. Furthermore, increased expression of MUC1 correlated with a poor prognosis, suggesting MUC1 to be a prognostic marker in ATL. Various functional analyses with knockdown experiments using a specific siRNA for MUC1 revealed that MUC1 is involved in cell growth, cell aggregation, and resistance to apoptosis. Although it has been shown that the anti-adhesive properties of MUC1 facilitate migration and metastasis of tumor cells, our findings indicated that MUC1 contributes to cell-cell adhesion. Mucins thus seem to play a role in the pathogenesis and/or progression of ATL.
Keywords: adhesion molecules / adult T-cell leukemia/lymphoma / apoptosis / MUC1
URI: http://hdl.handle.net/10069/27414
ISSN: 10428194
DOI: 10.3109/10428194.2011.559671
PubMed ID: 21599593
Rights: © 2011 Informa UK, Ltd. / This is an electronic version of an article published in Leukemia & Lymphoma, 52(6), pp.1108-1117; 2011. Leukemia & Lymphoma is available online at: http://dx.doi.org/10.3109/10428194.2011.559671
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27414

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