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Functional characterization of the regulators of calcineurin in Candida glabrata


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Title: Functional characterization of the regulators of calcineurin in Candida glabrata
Authors: Miyazaki, Taiga / Izumikawa, Koichi / Nagayoshi, Yohsuke / Saijo, Tomomi / Yamauchi, Shunsuke / Morinaga, Yoshitomo / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Miyazaki, Yoshitsugu / Kohno, Shigeru
Issue Date: Dec-2011
Publisher: Blackwell Publishing Inc.
Citation: FEMS Yeast Research, 11(8), pp.621-630; 2011
Abstract: The serine-threonine-specific protein phosphatase calcineurin is a key mediator of various stress responses in fungi. Herein, we characterized functions of the endogenous regulators of calcineurin (RCNs), Rcn1 and Rcn2, in the pathogenic fungus Candida glabrata. Rcn1 exerted both inhibitory and stimulatory effects on calcineurin signaling, but Rcn2 displayed only inhibitory activity. Phenotypic analyses of C. glabrata strains lacking either RCNs, calcineurin, or both revealed that calcineurin requires Rcn1, but not Rcn2, for antifungal tolerance in C. glabrata.
Keywords: Antifungal resistance / Crz1 / Rcn1 / Rcn2
URI: http://hdl.handle.net/10069/27451
ISSN: 15671356
DOI: 10.1111/j.1567-1364.2011.00751.x
Rights: © 2011 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. / The definitive version is available at www.blackwell-synergy.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/27451

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