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The incidence and distribution of biopsy-proven renal diseases in children


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タイトル: The incidence and distribution of biopsy-proven renal diseases in children
著者: Nakashima, Yumiko / Nazneen, Arifa / Abe, Kuniko / Nakayama, Toshiyuki / Taguchi, Takashi / Shirakawa, Toshihiko / Moriuchi, Hiroyuki
発行日: 2012年 4月
出版者: Nagasaki University School of Medicine / 長崎大学医学部
引用: Acta Medica Nagasakiensia, 57(1), pp.19-24; 2012
抄録: The precise distribution pattern of pediatric renal diseases has seldom been reported especially for young children. In order to clarify the incidence and distribution of renal diseases in children, 599 renal biopsy specimens obtained from 547 pediatric patients (≦15 years old) were analyzed by routine light, electron and immunofluorescence microscopy. Among the total biopsy cases, the most common renal disease identified in childhood was IgA glomerulonephritis (IgAGN; 37%). More than 80% of patients with IgAGN were discovered by urinary screening at the school, showing asymptomatic proteinuria and/or hematuria. The other major renal diseases were minor glomerular abnormality (12.2%), Henoch-Schönlein purpura nephritis (HSPN; 10.6%), and thin basement membrane disease (7.1%). One of the major causes of pediatric nephrotic syndrome were minimal change nephrotic syndrome (58%), whereas the other causes were IgAGN (11.6%), HSPN (8.9%), membranous glomerulonephritis (5.4%), membranoproliferative glomerulonephritis (3.6%). In conclusion, IgAGN was the most common renal disease also in children as in adolescence. From the age of seven years, the incidence of IgA-GN was highest among all the pediatric renal diseases during whole childhood period, and the incidence and number of the patients increased as they grow. On the other hand, there are also many cases with non-progressive clinical courses, such as minor glomerular abnormality and thin basement membrane disease in children. The renal biopsy following routine urinary screening at the school may be important for the therapeutic and prognostic guidelines of pediatric group of patients with renal diseases.
キーワード: renal disease / children / disease distribution / renal biopsy / IgA glomerulonephritis
URI: http://hdl.handle.net/10069/28548
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 57, No. 1

引用URI : http://hdl.handle.net/10069/28548

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