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Immune function in a patient with aspergillosis after lung transplantation: Case Report

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Title: Immune function in a patient with aspergillosis after lung transplantation: Case Report
Authors: Miyazaki, Takuro / Tagawa, Tsutomu / Yamasaki, Naoya / Tsuchiya, Tomoshi / Matsumoto, Keitaro / Tomoshige, Koichi / Tsuchihashi, Yoshiko / Morimoto, Konosuke / Nagayasu, Takeshi
Issue Date: Apr-2012
Publisher: Nagasaki University School of Medicine / 長崎大学医学部
Citation: Acta Medica Nagasakiensia, 57(1), pp.25-28; 2012
Abstract: We report a case that was successfully treated invasive pulmonary aspergillosis after living donor lobar lung transplantation and monitored patients' immune function with ImmuKnow® assay. A 43-year-old woman underwent living donor lobar lung transplantation for pulmonary alveolar proteinosis. Two healthy her relatives donated each lower lobe. Six months after transplantation, she was diagnosed as invasive pulmonary aspergillosis (IPA). During the anti-fungal treatment, one immunosuppressant was withdrawn and the trough level of calcineurin inhibitor was reduced to the minimum. Despite of such a low immunosuppressive status, Immuknow® assay showed that immune function was maintained in the moderate range, which encouraged us to keep this strategy for IPA. Immune evaluation by Immuknow® is useful method for monitoring and controlling patients' immune status especially in the infected condition, which revealed moderate immune level could be maintained with only two immunosuppressant drugs in the patient after recovery from IPA.
Keywords: lung transplantation / aspergillosis / immunosuppression
URI: http://hdl.handle.net/10069/28549
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 57, No. 1

Citable URI : http://hdl.handle.net/10069/28549

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