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Pre-vaccination epidemiology of human papillomavirus infections in Japanese women with abnormal cytology.


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Title: Pre-vaccination epidemiology of human papillomavirus infections in Japanese women with abnormal cytology.
Authors: Yamasaki, Kentaro / Miura, Kiyonori / Shimada, Takako / Ikemoto, Rie / Miura, Shoko / Murakami, Makoto / Sameshima, Tetsuro / Fujishita, Akira / Kotera, Kouhei / Kinoshita, Akira / Yoshiura, Koh-Ichiro / Masuzaki, Hideaki
Issue Date: Nov-2011
Publisher: Blackwell Pub. Asia
Citation: The Journal of Obstetrics and Gynaecology Research, 37(11), pp.1666-1670; 2011
Abstract: To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in women with abnormal cytology in Nagasaki, Japan. We performed Pap smear tests, biopsies and HPV genotype testing in Nagasaki Prefecture from August 2007 through November 2009. During the study period, serial samples of uterine cervical specimens were obtained from 539 subjects with abnormal cytology and/or squamous intraepithelial lesions (SIL) confirmed previously, or with clinically suspected invasive cervical cancer. In 119 HPV-positive subjects with low-grade SIL, the three most prevalent high-risk HPV genotypes were HPV52 (21.8%; 26/119), HPV16 (20.2%; 24/119) and HPV56 (17.6%; 21/119). In 199 women, 127 HPV-positive subjects with high-grade SIL and 67 HPV-positive subjects with squamous cell carcinoma (SCC), the three most prevalent high-risk HPV genotypes were HPV16 (44.3%; 86/194), HPV52 (20.6%; 40/194) and HPV58 (16.0%; 31/194). Compared with the distribution of high-risk HPV genotypes in other countries, HPV52 was a more common genotype in Nagasaki. With disease progression to SCC, the distribution of high-risk HPV56 belonging to the A6 HPV family decreased, while HPV16 and HPV52 belonging to the A9 HPV family persisted. Our data provide an important resource to address the case for vaccination against HPV genotypes other than HPV16 and HPV18 in Japan.
Keywords: adult / aged / article / cytodiagnosis / female / genetics / genotype / human / Japan / middle aged / Papilloma virus / papillomavirus infection / pathology / prevalence / squamous cell carcinoma / uterine cervix / uterine cervix carcinoma in situ / uterine cervix tumor / vagina smear / virology / 80 and over / Carcinoma / Squamous Cell / Cervical Intraepithelial Neoplasia / Cervix Uteri / Cytodiagnosis / Female / Genotype / Humans / Papillomaviridae / Papillomavirus Infections / Uterine Cervical Neoplasms / Vaginal Smears / Medline is the source for the MeSH terms of this document
URI: http://hdl.handle.net/10069/28792
ISSN: 14470756
DOI: 10.1111/j.1447-0756.2011.01601.x
PubMed ID: 21793993
Rights: © 2011 The Authors. Journal of Obstetrics and Gynaecology Research / © 2011 Japan Society of Obstetrics and Gynecology / The definitive version is available at Wiley Online Library , www.wileyonlinelibrary.com.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/28792

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