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Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging

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Title: Protective Effects of Corni Fructus against Advanced Glycation Endproducts and Radical Scavenging
Authors: Park, Chan Hum / Tanaka, Takashi / Kim, Hyun Young / Park, Jong Cheol / Yokozawa, Takako
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation: Evidence-Based Complementary and Alternative Medicine, 2012, 418953; 2012
Abstract: We investigated the inhibition of advanced glycation endproduct (AGE) activity using the fluorescence characteristics of fractions and compounds from Corni Fructus. Corni Fructus extract and its iridoid glycoside components showed low inhibitory activities as well as the AGE inhibitor aminoguanidine. However, a low molecular weight polyphenol, 7-O-galloyl-D-sedoheptulose, and an antioxidant, trolox, showed high inhibitory activities compared with aminoguanidine under reactive conditions. The AGE-inhibiting activity of polyphenolic fractions of Corni Fructus ranged from a level comparable to Corni Fructus extract to the higher level of 7-O-galloyl-D-sedoheptulose. As well as the results of AGE-inhibiting activity, Corni Fructus extract and iridoid components showed low or no 1,1-diphenyl-2-pycrylhydrazyl (DPPH) radical-scavenging activities, whereas 7-O-galloyl-D-sedoheptulose showed a level comparable to trolox. Polyphenolic fractions of Corni Fructus quenched DPPH radicals in a concentration-dependent manner. Some fractions exerted a higher DPPH radical-scavenging activity compared with trolox and 7-O-galloyl-D-sedoheptulose. The DPPH radical-scavenging activity was significantly correlated with the AGE-inhibiting activity. These results suggest that polyphenolic fractions of Corni Fructus inhibited AGE formation by antioxidant activity including free radical scavenging. The strong DPPH radical-scavenging and AGE-inhibiting fractions included ellagitannins and polymeric proanthocyanidins.
Keywords: 1 / 1 diphenyl 2 picrylhydrazyl / 7 o galloyl dextro sedoheptulose / advanced glycation end product / aminoguanidine / Corni fructus extract / Cornus officinalis extract / cornuside / ellagitannin / glycoside / iridoid / loganin / morroniside / para coumaric acid / plant extract / polyphenol / proanthocyanidin derivative / quercetin glucuronide / scavenger / trolox C / unclassified drug / article / concentration response / controlled study / drug isolation / drug structure / fluorescence / in vitro study / priority journal / solvent extraction
URI: http://hdl.handle.net/10069/29406
ISSN: 1741427X
DOI: 10.1155/2012/418953
Rights: Copyright © 2012 Chan Hum Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/29406

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