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Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation


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Title: Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation
Authors: Ozeki, Ayumi / Suzuki, Keiji / Suzuki, Masatoshi / Ozawa, Hiroki / Yamashita, Shunichi
Issue Date: 28-Mar-2012
Publisher: Lippincott Williams and Wilkins
Citation: NeuroReport, 23(5), pp.290-293; 2012
Abstract: Neural stem cells (NSCs) are highly susceptible to DNA double-strand breaks; however, little is known about the effects of radiation in cells surviving radiation. Although the nestin-positive NSCs predominantly became glial fibrillary acidic protein (GFAP)-positive in differentiation-permissive medium, little or no cells were GFAP positive in proliferation-permissive medium. We found that more than half of the cells surviving X-rays became GFAP positive in proliferation-permissive medium. Moreover, localized irradiation stimulated differentiation of cells outside the irradiated area. These results indicate for the first time that ionizing radiation is able to stimulate astrocyte-specific differentiation of surviving NSCs, whose process is mediated both by the direct activation of nuclear factor-jB and by the indirect bystander effect induced by X-irradiation.
Keywords: Bystander signal / Glial fibrillary acidic protein / Nuclear factor-jB / X-ray
URI: http://hdl.handle.net/10069/29510
ISSN: 09594965
DOI: 10.1097/WNR.0b013e3283509a79
Relational Links: http://hdl.handle.net/10069/28800
Rights: © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins. / This is a non-final version of an article published in final form in NeuroReport, 23(5), pp.290-293; 2012.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/29510

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