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The PI3K/Akt Pathway Contributes to Arenavirus Budding

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Title: The PI3K/Akt Pathway Contributes to Arenavirus Budding
Authors: Urata, Shuzo / Ngo, Nhi / de la Torre, Juan Carlos
Issue Date: Apr-2012
Publisher: American Society for Microbiology
Citation: Journal of Virology, 86(8), pp.4578-4585; 2012
Abstract: Several arenaviruses, chiefly Lassa virus (LASV), cause hemorrhagic fever (HF) disease in humans and pose a significant public health concern in regions where they are endemic. On the other hand, evidence indicates that the globally distributed prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway participates in many cellular processes, including cell survival and differentiation, and also has been shown to play important roles in different steps of the life cycles of a variety of viruses. Here we report that the inhibition of the PI3K/Akt pathway inhibited budding and to a lesser extent RNA synthesis, but not cell entry, of LCMV. Accordingly, BEZ-235, a PI3K inhibitor currently in cancer clinical trials, inhibited LCMV multiplication in cultured cells. These findings, together with those previously reported for Junin virus (JUNV), indicate that targeting the PI3K/Akt pathway could represent a novel antiviral strategy to combat human-pathogenic arenaviruses.
Keywords: 1 (1 cyano 1 methylethyl) 3 methyl 8 (3 quinolinyl)imidazo[4,5 c]quinolin 2(1h,3h) one / phosphatidylinositol 3 kinase / protein kinase B / rapamycin / virus RNA / antiviral activity / article / cell culture / controlled study / drug effect / drug mechanism / drug targeting / enzyme activity / enzyme inhibition / genetic transcription / Lymphocytic choriomeningitis virus / priority journal / protein targeting / RNA replication / virogenesis / virus entry / virus gene / virus inhibition / virus release / Animals / Arenavirus / Cell Line / Cercopithecus aethiops / Chromones / Gene Expression Regulation, Viral / Humans / Imidazoles / Lassa virus / Lymphocytic choriomeningitis virus / Morpholines / Phosphatidylinositol 3-Kinases / Proto-Oncogene Proteins c-akt / Quinolines / RNA, Viral / Signal Transduction / Sirolimus / Virus Internalization / Virus Release / Virus Replication
URI: http://hdl.handle.net/10069/30198
ISSN: 0022538X
DOI: 10.1128/JVI.06604-11
Rights: © 2012, American Society for Microbiology.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/30198

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