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Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma

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Title: Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma
Authors: Yanamoto, Souichi / Yamada, Shinichi / Takahashi, Hidenori / Yoshitomi, Izumi / Kawasaki, Goro / Ikeda, Hisazumi / Minamizato, Tokutarou / Shiraishi, Takeshi / Fujita, Shuichi / Ikeda, Tohru / Asahina, Izumi / Umeda, Masahiro
Issue Date: Oct-2012
Publisher: International Association of Oral and Maxillofacial Surgeons
Citation: International Journal of Oral and Maxillofacial Surgery, 41(10), pp.1195-1200; 2012
Abstract: Local recurrence of oral squamous cell carcinoma (OSCC) after primary surgery has been considered to be a poor prognostic entity in terms of survival rate. The purpose of this study is to evaluate the incidence of local recurrence and to identify significant risk factors for the local recurrence in OSCC. The authors retrospectively reviewed records for 187 patients who underwent radical surgery for OSCC. The local recurrence rate was 16.0% (30/187 patients) in this study. The survival rate of patients with local recurrence was 33.3%, which was significantly lower than that (94.3%) of patients without local recurrence. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC), and the status of the surgical margin were identified as factors influencing local recurrence. In particular, NAC and the status of the surgical margin were independent risk factors by multivariate analysis. The deep margin was resected at a close site in many NAC-treated patients, suggesting that NAC may lead to local recurrence and poor outcomes. No efficacy of NAC was observed, suggesting that the standard treatment of oral cancers is surgery alone.
Keywords: local recurrence / neoadjuvant chemotherapy / oral squamous cell carcinoma / surgical margin
URI: http://hdl.handle.net/10069/30254
ISSN: 09015027
DOI: 10.1016/j.ijom.2012.07.011
Rights: © 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. / NOTICE: this is the author’s version of a work that was accepted for publication in International Journal of Oral and Maxillofacial Surgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Oral and Maxillofacial Surgery, 41, 10(2012)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/30254

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