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Expression of angiotensin II type 1 receptor in rat bladder smooth muscle cells in response to a streptzotocin induced diabetes mellitus model


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Title: Expression of angiotensin II type 1 receptor in rat bladder smooth muscle cells in response to a streptzotocin induced diabetes mellitus model
Authors: Tobu, Shohei / Noguchi, Mitsuru / Hatada, Teppei / Mori, Ken-ichi / Matsuo, Manabu / Sakai, Hideki
Issue Date: Sep-2012
Publisher: S. Karger AG
Citation: Current Urology, 6(2), pp.62-66; 2012
Abstract: Introduction: The aim of this study was to investigate angiotensin II type 1 (AT1) receptors in rat bladder smooth muscle cells and alterations of AT1 receptors by diabetes mellitus and diuretic states. Materials and Methods: Diabetes and diuresis were induced in adult female rats by a single intraperitoneal injection of streptozotocin and feeding 5% sucrose in water. Cystometry was performed on control, diuretic, and diabetic rats at 2 and 8 weeks after treatment. Immunohistochemical staining was used to detect expression of AT1 receptors in the bladder smooth muscle cell membrane. Results and Conclusions: In diabetic rats, expression of AT1 receptors in the bladder smooth muscle cell membrane increased at 2 weeks and further increased at 8 weeks. The local renin-angiotensin system in the rat bladder might be activated by the continuous hyperglycemia caused by intraperitoneal injection of streptozotocin administration.
Keywords: Angiotensin receptor / Bladder / Diabetes mellitus / Renin-angiotensin system
URI: http://hdl.handle.net/10069/30707
ISSN: 16617649
DOI: 10.1159/000343510
Rights: © 2012 S. Karger AG, Basel.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/30707

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