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Evaluation of Surgical Resection for Gallbladder Carcinoma at a Japanese Cancer Institute


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Title: Evaluation of Surgical Resection for Gallbladder Carcinoma at a Japanese Cancer Institute
Authors: Nanashima, Atsushi / Tobinaga, Syuuichi / Abo, Takafumi / Morisaki, Tomohito / Uehara, Ryouhei / Takeshita, Hiroaki / Nonaka, Takashi / Hidaka, Shigekazu / Takeshima, Fuminao / Ohnita, Ken / Isomoto, Hajime / Kunizaki, Masaki / Sawai, Terumitsu / Nakao, Kazuhiko / Nagayasu, Takeshi
Issue Date: Sep-2012
Publisher: H.G.E. Update Medical Publishing Ltd.
Citation: Hepato-gastroenterology, 59(118), pp.1717-1721; 2012
Abstract: Background/Aims: Surgical resection is a radical treatment option for gallbladder carcinoma (GBC); however, it is still difficult to cure and patient prognosis is poor. An assessment of the surgical results and chemotherapy options may elucidate effective treatments. Methodology: We retrospectively examined the demographics, surgical records and outcome in 33 patients with GBC undergoing surgical resection. Results: Postoperative cancer recurrence was observed in 36% of patients. Mean cancer-free survival time was 84 months and 3-year cancer-free survival rate was 70% Mean overall survival time was 96 months and 5-year overall survival rate was 52%. The 3-year cancer-free survival and the 5-year overall survival were significantly different between the final tumor stages (p<0.001). Higher CEA and CA19-9 level were significantly related to poor overall survival (p<0.05). Macroscopically, papillary type tumor showed significantly better overall survival compared to nodular or flat types (p<0.05). Degree of invasion, node metastasis, moderate or poor differentiation, vascular or perineural invasion and invasion of the liver or hepatoduodenal ligament were significantly associated with poor overall survival (p<0.05). A cancer-free margin at the hepatic cut end and dissected periductal structures showed a significantly poor prognosis (p<0.05). The overall survival in final curability A was significantly associated with better curability than B or C (p<0.05). Conclusions: Radically extended surgical resection for GBC is necessary to obtain improved patient survival and new adjuvant chemotherapy would be expected to improve results after surgery.
Keywords: Curability / Gallbladder carcinoma / Stage / Survival / Tumor markers
URI: http://hdl.handle.net/10069/30981
ISSN: 01726390
DOI: 10.5754/hge10299
PubMed ID: 22819898
Rights: © H.G.E. Update Medical Publishing S.A.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/30981

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