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Relationship between Microvessel Count and Clinicopathological Characteristics and Postoperative Survival in Patients with Pancreatic Carcinoma

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Title: Relationship between Microvessel Count and Clinicopathological Characteristics and Postoperative Survival in Patients with Pancreatic Carcinoma
Authors: Nanashima, Atsushi / Shibata, Kenichirou / Nakayama, Toshiyuki / Abo, Takafumi / Nonaka, Takashi / Fukuda, Daisuke / Fukuoka, Hidetoshi / Hidaka, Shigekazu / Takeshita, Hiroaki / Sawai, Terumitsu / Yasutake, Toru / Nagayasu, Takeshi
Issue Date: Sep-2012
Publisher: H.G.E. Update Medical Publishing Ltd.
Citation: Hepato-gastroenterology, 59(118), pp.1964-1969; 2012
Abstract: Background/Aims: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and clinicopathological characteristics or prognosis in pancreatic carcinoma (PC) patients who underwent hepatectomy. Methodology: CD34 expression was analyzed using immunohistochemical methods. Mean MVC in 5 areas per specimen and clinicopathological factors were consecutively examined in 42 PC patients. Results: Median MVC for PC patients was 123/mm2, which was applied as a cut-off value. Higher MVC was significantly associated with the advanced Japanese tumor-node-metastasis stage IVa and IVb (p=0.034). Univariate survival analysis identified higher carcinoembryonic antigen (CEA) and CA19-9 level, infiltrative type on macroscopic examination, invasive ductal carcinoma, node metastasis and higher tumor-node-metastasis classification were significantly associated with poor survival. The 5-year overall survival rate in the higher MVC group tended to be lower than that in the higher MVC group (37 vs. 55%), but not statistically significant (p=0.15). Conclusions: Tumor MVC might be a candidate prognostic marker of PC patient survival after pancreatectomy and further investigation in a larger series is warranted to clarify the significance of this marker.
Keywords: CD34 / Microvessel count / Pancreatic carcinoma / Pancreatic resection / Survival
URI: http://hdl.handle.net/10069/30982
ISSN: 01726390
DOI: 10.5754/hge10618
PubMed ID: 22819916
Rights: © H.G.E. Update Medical Publishing S.A.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/30982

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