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Effects of Nasal Continuous Positive Airway Pressure on Left Ventricular Concentric Hypertrophy in Obstructive Sleep Apnea Syndrome


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タイトル: Effects of Nasal Continuous Positive Airway Pressure on Left Ventricular Concentric Hypertrophy in Obstructive Sleep Apnea Syndrome
著者: Koga, Seiji / Ikeda, Satoshi / Nakata, Tomoo / Yasunaga, Tomohiko / Maemura, Koji
発行日: 2012年10月15日
出版者: 日本内科学会 / Japanese Society of Internal Medicine
引用: Internal Medicine, 51(20), pp.2863-2868; 2012
抄録: Objective Abnormal left ventricular (LV) geometry, especially concentric hypertrophy, is associated with cardiovascular morbidity and mortality. The aim of this study was to evaluate the impact of obstructive sleep apnea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on the LV geometric patterns. Methods The LV morphological parameters, including the LV mass index (LVMI) and the relative wall thickness (RWT), were evaluated using echocardiography in 37 patients with OSAS diagnosed on polysomnography and 34 control subjects. Based on the values of LVMI and RWT, the LV geometry was classified as normal, concentric remodeling, concentric hypertrophy or eccentric hypertrophy. The echocardiographic parameters were reassessed after three months of CPAP treatment. Results Compared with the controls, the OSAS patients had a higher proportion of concentric hypertrophy patterns (54% vs. 0%, p<0.001) and a lower proportion of normal geometric patterns (5% vs. 62%, p<0.001). A univariate logistic regression analysis showed the apnea-hypopnea index, lowest oxygen saturation, hypoxemia index and body mass index to each be significantly associated with the presence of concentric hypertrophy. In a multivariate analysis of these factors, the apnea-hypopnea index was found to be a significant independent factor associated with the presence of concentric hypertrophy (odds ratio: 1.06, p=0.008). Three months of CPAP treatment resulted in significant decreases in LVMI and the proportion of cases with concentric hypertrophy (both p=0.025). Conclusion In our limited study population, OSAS patients were found to be associated with a high prevalence of concentric LV hypertrophy patterns that were able to be reversed with three months of CPAP treatment.
キーワード: Continuous positive airway pressure / Left ventricular hypertrophy / Obstructive sleep apnea syndrome
URI: http://hdl.handle.net/10069/30992
ISSN: 09182918
DOI: 10.2169/internalmedicine.51.8062
権利: © 2012 The Japanese Society of Internal Medicine.
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/30992

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