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Serum S-glutathionylated proteins as a potential biomarker of carotid artery stenosis


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Title: Serum S-glutathionylated proteins as a potential biomarker of carotid artery stenosis
Authors: Nakamoto, Morito / Hirose, Makoto / Kawakatsu, Miho / Nakayama, Toshiyuki / Urata, Yoshishige / Kamata, Kensaku / Kaminogo, Makio / Li, Tao-Sheng / Nagata, Izumi
Issue Date: Nov-2012
Publisher: Elsevier Inc.
Citation: Clinical Biochemistry, 45(16-17), pp.1331-1335; 2012
Abstract: Objectives: As oxidative stress is known to be associated with the development of atherosclerosis, we investigated whether the serum S-glutathionylated proteins were increased in patients with carotid artery stenosis (CS). Design and methods: Fifty-four patients with CS and 20 age-matched non-CS patients were involved in this study. S-glutathionylated proteins in serum were examined by immunoblot analysis using an antibody against S-glutathionylated bovine serum albumin. Results: The antibody against S-glutathionylated bovine serum albumin was confirmed to specifically recognize the serum S-glutathionylated proteins in patient samples. The S-glutathionylated proteins in serum were significantly increased in the patients with CS (p<. 0.01) compared to the non-CS patients, and the increase did not depend on the stage of CS. Logistic regression analysis revealed that the serum levels of S-glutathionylated proteins were associated with the development of CS (p<. 0.01). Conclusions: Oxidative stress likely contributes to the development of CS, and serum S-glutathionylated proteins may be a potential biomarker of CS.
Keywords: Carotid artery stenosis / Oxidative stress / S-Glutathionylated protein
URI: http://hdl.handle.net/10069/31006
ISSN: 00099120
DOI: 10.1016/j.clinbiochem.2012.06.017
Relational Links: http://hdl.handle.net/10069/32632
Rights: © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. / NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Biochemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Biochemistry, 45, 16-17(2012)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31006

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