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Prognosis of Thyroid Nodules in Individuals Living in the Zhitomir Region of Ukraine


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Title: Prognosis of Thyroid Nodules in Individuals Living in the Zhitomir Region of Ukraine
Authors: Hayashida, Naomi / Sekitani, Yui / Takahashi, Jumpei / Kozlovsky, Alexander A. / Gutevych, Oleksandr K. / Saiko, Aleksey S. / Nirova, Nina V. / Petrova, Anjela A. / Rafalskiy, Ruslan M. / Chorny, Sergey A. / Daniliuk, Valery V. / Anami, Masanobu / Yamashita, Shunichi / Takamura, Noboru
Issue Date: 28-Nov-2012
Publisher: Public Library of Science
Citation: PLoS ONE, 7(11), e50648; 2012
Abstract: Objective: After the accident at the Chernobyl Nuclear Power Plant (CNPP), the incidence of thyroid cancer increased among children. Recently, a strong relationship between solid thyroid nodules and the incidence of thyroid cancer was shown in atomic bomb survivors. To assess the prognosis of benign thyroid nodules in individuals living in the Zhitomir region of Ukraine, around the CNPP, we conducted a follow-up investigation of screening data from 1991 to 2000 in the Ukraine. Patients and Methods: Participants of this study were 160 inhabitants with thyroid nodules (nodule group) and 160 inhabitants without thyroid nodules (normal control group) intially identified by ultrasonography from 1991 to 2000. All participants were aged 0 to 10 years old and lived in the same area at the time of the accident. We performed follow-up screening of participants and assessed thyroid nodules by fine needle aspiration biopsy. Results: Among the nodule group participants, the number and size of nodules were significantly increased at the follow-up screening compared with the initial screening. No thyroid nodules were observed among the normal control group participants. The prevalence of thyroid abnormality, especially nodules that could be cancerous (malignant or suspicious by fine needle aspiration biopsy), was 7.5% in the nodule group and 0% in the normal control group (P<0.001). Conclusions: Our study indicated that a thyroid nodule in childhood is a prognostic factor associated with an increase in the number and size of nodules in individuals living in the Zhitomir region of Ukraine.
URI: http://hdl.handle.net/10069/31112
DOI: 10.1371/journal.pone.0050648
Rights: © 2012 Hayashida et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31112

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