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Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney


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Title: Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney
Authors: Park, Chan Hum / Lee, Sul Lim / Okamoto, Takuya / Tanaka, Takashi / Yokozawa, Takako
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation: Evidence-Based Complementary and Alternative Medicine, 2012, 587902; 2012
Abstract: Two Rokumi-jio-gan-containing prescriptions (Hachimi-jio-gan and Bakumi-jio-gan) were selected to examine their actions in nephrectomized rats. Each prescription was given orally to rats for 10 weeks after the excision of five-sixths of their kidney volumes, and its effect was compared with non-nephrectomized and normal rats. Rats given Hachimi-jio-gan and Bakumi-jio-gan showed an improvement of renal functional parameters such as serum urea nitrogen, creatinine, creatinine clearance, and urinary protein. The nephrectomized rats exhibited the up-regulation of nicotinamide adenine dinucleotide phosphate oxidase subunits, c-Jun N-terminal kinase (JNK), phosphor-JNK, c-Jun, transforming growth factor-β nuclear factor-kappa B, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, intracellular adhesion molecule-1, Bax, cytochrome c, and caspase-3, and down-regulation of NF-E2-related factor 2, heme oxygenase-1, and survivin; however, Bakumi-jio-gan administration acts as a regulator in inflammatory reactions caused by oxidative stress in renal failure. Moreover, the JNK pathway and apoptosis-related protein expressions, Bax, caspase-3, and survivin, were ameliorated to the normal levels by Hachimi-jio-gan administration. The development of renal lesions, glomerular sclerosis, tubulointerstitial damage, and arteriolar sclerotic lesions, estimated by histopathological evaluation and scoring, was strong in the groups administered Hachimi-jio-gan rather than Bakumi-jio-gan. This study suggests that Rokumi-jio-gan-containing prescriptions play a protective role in the progression of renal failure.
Keywords: bakumijiogan / caspase 3 / creatinine / cyclooxygenase 2 / cytochrome c / hachimijiogan / heme oxygenase 1 / immunoglobulin enhancer binding protein / inducible nitric oxide synthase / intercellular adhesion molecule 1 / monocyte chemotactic protein 1 / plant medicinal product / protein Bax / protein c jun / reduced nicotinamide adenine dinucleotide phosphate oxidase / reduced nicotinamide adenine dinucleotide phosphate oxidase 4 / stress activated protein kinase / survivin / transcription factor NF E2 / transcription factor Nrf2 / transforming growth factor beta1 / unclassified drug / animal experiment / animal model / animal tissue / apoptosis / arteriolosclerosis / article / controlled study / creatinine clearance / down regulation / fluid intake / food intake / glomerulosclerosis / histopathology / inflammation / interstitial nephritis / kidney failure / kidney function / kidney parenchyma / male / nephrectomy / nonhuman / oxidative stress / prescription / priority journal / protein expression / protein urine level / rat / upregulation / urea nitrogen blood level / weight change
URI: http://hdl.handle.net/10069/31215
ISSN: 1741427X
DOI: 10.1155/2012/587902
Rights: © 2012 Chan Hum Park et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31215

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