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腎臓内科のためのDDS技術


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Title: 腎臓内科のためのDDS技術
Other Titles: Technologies of Drug Delivery System for Nephrology
Authors: 小畑, 陽子 / 西野, 友哉 / 河野, 茂
Authors (alternative): Obata, Yoko / Nishino, Tomoya / Kohno, Shigeru
Issue Date: 28-Dec-2012
Publisher: 日本DDS学会 / Japan Society of Drug Delivery System
Citation: Drug Delivery System, 27(4), pp.257-266; 2012
Abstract: 近年、慢性腎臓病が末期腎不全ならびに心血管疾患の危険因子であることが明らかとなってきており,慢性腎臓病への対策を講じることは透析導入患者数の増加に歯止めをかけると共に心血管疾患の発症を防止することにも繋がり、大変重要と考えられる。しかしながら、末期腎不全でみられる糸球体硬化や腎間質線維化に対する根本的な治療方法はいまだ確立されていない。そこで、本稿では、臓器線維化に対するdrug delivery system (DDS)を応用した再生誘導治療の試みを中心とした、腎臓内科分野におけるDDS技術について概説する。 / Chronic kidney disease (CKD) is known to be a risk factor for end stage renal disease (ESRD) and cardiovascular disease. Therefore, the development of new treatments for CKD is important and necessary. However, there is no established therapy for glomerulosclerosis and renal interstitial fibrosis, which are seen in the kidney of ESRD patients. Recent advances in basic research on the mechanism of fibrosis leads to discovery of fibrosis relating genes or factors. Some anti-fibrotic approaches for targeting these factors have been reported. In this review, we introduce several technologies and methodology using drug delivery system for fibrosis in nephrology.
Keywords: fibrosis / cationized gelatin / small interfering RNA / gene-cell hybrid therapy
URI: http://hdl.handle.net/10069/31248
ISSN: 09135006
DOI: 10.2745/dds.27.257
Rights: © 2012 日本DDS学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31248

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