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Molecular Epidemiology and Disease Severity of Human Respiratory Syncytial Virus in Vietnam


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Title: Molecular Epidemiology and Disease Severity of Human Respiratory Syncytial Virus in Vietnam
Authors: Tran, Dinh Nguyen / Pham, Thi Minh Hong / Ha, Manh Tuan / Tran, Thi Thu Loan / Dang, Thi Kim Huyen / Yoshida, Lay-Myint / Okitsu, Shoko / Hayakawa, Satoshi / Mizuguchi, Masashi / Ushijima, Hiroshi
Issue Date: 22-Jan-2013
Publisher: Public Library of Science
Citation: PLoS ONE, 8(1), e45436; 2013
Abstract: Respiratory syncytial virus (RSV) is a major cause of acute respiratory infections (ARIs) in children worldwide and can cause high mortality, especially in developing countries. However, information on the clinical and molecular characteristics of RSV infection in developing countries is limited. From April 2010 to May 2011, 1,082 nasopharyngeal swabs were collected from children with ARI admitted to the Children's Hospital 2, Ho Chi Minh City, Vietnam. Samples were screened for RSV and genotyped by reverse transcription-PCR and sequencing. Demographic and clinical data was also recorded. RSV was found in 23.8% (257/1,082) of samples. RSV A was the dominant subgroup, accounting for 91.4% (235/257), followed by RSV B, 5.1% (13/257), and 9 cases (3.5%) were mixed infection of these subgroups. The phylogenetic analysis revealed that all group A strains belonged to the GA2 genotype. All group B strains belonged to the recently identified BA genotype, and further clustered into 2 recently described subgenotypes BA9 and BA10. One GA2 genotype strain had a premature stop codon which shortened the G protein length. RSV infection was significantly associated with younger age and higher severity score than those without. Co-infection with other viruses did not affect disease severity. RSV A caused more severe disease than RSV B. The results from this study will not only contribute to the growing database on the molecular diversity of RSV circulating worldwide but may be also useful in clinical management and vaccine development.
URI: http://hdl.handle.net/10069/31414
DOI: 10.1371/journal.pone.0045436
Rights: © 2013 Tran et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31414

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