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Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries


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Title: Autologous adipose-derived regenerative cells are effective for chronic intractable radiation injuries
Authors: Akita, Sadanori / Yoshimoto, Hiroshi / Ohtsuru, Akira / Hirano, Akiyoshi / Yamashita, Shunichi
Issue Date: Oct-2012
Publisher: Oxford University Press
Citation: Radiation Protection Dosimetry, 151(4), pp.656-660; 2012
Abstract: Effective therapy for chronic radiation injuries, such as ulcers, is prone to infection. Stiffness is expected since the therapeutic radiation often involves wider and deeper tissues and often requires extensive debridement and reconstruction, which are not sometimes appropriate for elderly and compromised hosts. Autologous adipose-derived regenerative cells (ADRCs) are highly yielding, forming relatively elderly aged consecutive 10 cases, 63.6±14.9 y (52-89 y), with mean radiation dose of 75.0±35.4 Gy (50-120 Gy) were included with at least 10-month follow-up. Minimal debridement and ADRC injection in the wound bed and margin along with the injection of mixture of fat and ADRCs in the periphery were tested for efficacy and regenerated tissue quality by clinically as well as imaging by computed tomography and magnetic resonance imaging. Uncultured ADRCs of 1.6±1.3×10. 7 cells were obtained. All cases healed uneventfully after 6.6±3.2 weeks (2-10 weeks) post-operatively. The done site morbidity was negligible and without major complications, such as paralysis or massive haematoma. The regenerated tissue quality was significantly superior to the pre-operative one and the mixture of fat and ADRCs connected to the intact tissue was very soft and pliable. Mean follow-up at 1.9±0.8 y (0.9-2.9 y) revealed no recurrence or new ulceration after treatment. Thus, the ADRCs treatment for decades-long radiation injuries is effective, safe and improves the quality of wounds.
URI: http://hdl.handle.net/10069/31879
ISSN: 01448420
DOI: 10.1093/rpd/ncs176
Rights: © World Health Organization 2012. All rights reserved. The World Health Organization has granted Oxford University Press permission for the reproduction of this article. / This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Radiation Protection Dosimetry following peer review. The definitive publisher-authenticated version Radiation Protection Dosimetry, 151(4), pp.656-660; 2012 is available online at: http://dx.doi.org/10.1093/rpd/ncs176
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31879

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