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Mesenchymal Stem Cell Therapy for Cutaneous Radiation Syndrome

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Title: Mesenchymal Stem Cell Therapy for Cutaneous Radiation Syndrome
Authors: Akita, Sadanori / Akino, Kozo / Hirano, Akiyoshi / Ohtsuru, Akira / Yamashita, Shunichi
Issue Date: Jun-2010
Publisher: Lippincott Williams and Wilkins
Citation: Health Physics, 98(6), pp.858-862; 2010
Abstract: Systemic and local radiation injuries caused by nuclear power reactor accidents, therapeutic irradiation, or nuclear terrorism should be prevented or properly treated in order to improve wound management and save lives. Currently, regenerative surgical modalities should be attempted with temporal artificial dermis impregnated and sprayed with a local angiogenic factor such as basic fibroblast growth factor, and secondary reconstruction can be a candidate for demarcation and saving the donor morbidity. Human mesenchymal stem cells and adipose-derived stem cells, together with angiogenic and mitogenic factor of basic fibroblast growth factor and an artificial dermis, were applied over the excised irradiated skin defect and were tested for differentiation and local stimulation effects in the radiation-exposed wounds. The perforator flap and artificial dermal template with growth factor were successful for reconstruction in patients who were suffering from complex underlying disease. Patients were uneventfully treated with minimal morbidities. In the experiments, the hMSCs are strongly proliferative even after 20 Gy irradiation in vitro. In vivo, 4 Gy rat whole body irradiation demonstrated that sustained marrow stromal (mesenchymal stem) cells survived in the bone marrow. Immediate artificial dermis application impregnated with cells and the cytokine over the 20 Gy irradiated skin and soft tissues demonstrated the significantly improved fat angiogenesis, architected dermal reconstitution, and less inflammatory epidermal recovery. Detailed understanding of underlying diseases and rational reconstructive procedures brings about good outcomes for difficult irradiated wound healing. Adipose-derived stem cells are also implicated in the limited local injuries for short cell harvesting and processing time in the same subject.
Keywords: Exposure / Radiation / Radiation damage / Radiotherapy / World Health Organization
URI: http://hdl.handle.net/10069/31916
ISSN: 00179078
DOI: 10.1097/HP.0b013e3181d3d52c
Rights: © 2010 Health Physics Society. / This is a non-final version of an article published in final form in Health Physics, 98(6), pp.858-862; 2010
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/31916

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