DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Graduate School of Biomedical Sciences > Articles in academic journal >

Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion


File Description SizeFormat
FroGen3_306.pdf1.73 MBAdobe PDFView/Open

Title: Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion
Authors: Ishikawa, Toshihisa / Toyoda, Yu / Yoshiura, Koh-ichiro / Niikawa, Norio
Issue Date: 2-Jan-2013
Publisher: Frontiers Media S.A.
Citation: Frontiers in Genetics, 3, Article 306; 2013
Abstract: Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained within secretory vesicles and are released during secretion as cytoplasmic fragments into the glandular lumen or interstitial space. The recent finding that the non-synonymous single nucleotide polymorphisms (SNP) 538G > A (rs17822931; Gly180Arg) in the ABCC11 gene determines the type of earwax in humans has shed light on the novel function of this ABC (ATP-binding cassette) transporter in apocrine glands. The wild-type (Gly180) of ABCC11 is associated with wet-type earwax, axillary osmidrosis, and colostrum secretion from the mammary gland as well as the potential risk of mastopathy. Furthermore, the SNP (538G > A) in the ABCC11 gene is suggested to be a clinical biomarker for the prediction of chemotherapeutic efficacy. The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients’ response to nucleoside-based chemotherapy.
Keywords: 5-fluorouracil / Apocrine gland / Axillary osmidrosis / Breast cancer / Earwax / Mastopathy / Tamoxifen
URI: http://hdl.handle.net/10069/32549
DOI: 10.3389/fgene.2012.00306
Rights: © 2013 Ishikawa, Toyoda, Yoshiura and Niikawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/32549

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace