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Sweet's Syndrome Complicated by Kikuchi's Disease and Hemophagocytic Syndrome which Presented with Retinoic Acid-inducible Gene-I in both the Skin Epidermal Basal Layer and the Cervical Lymph Nodes


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Title: Sweet's Syndrome Complicated by Kikuchi's Disease and Hemophagocytic Syndrome which Presented with Retinoic Acid-inducible Gene-I in both the Skin Epidermal Basal Layer and the Cervical Lymph Nodes
Authors: Koga, Tomohiro / Takano, Kanako / Horai, Yoshiro / Yamasaki, Satoshi / Nakamura, Hideki / Mizokami, Akinari / Ohshima, Koichi / Kawakami, Atsushi
Issue Date: 15-Aug-2013
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 52(16), pp.1839-1843; 2013
Abstract: A 21-year-old man was admitted to our hospital with a fever, erythema, cervical lymphadenopathy and pancytopenia. A diagnosis of Sweet's syndrome (SS) with Kikuchi's disease (KD) and hemophagocytic syndrome (HPS) was made based on the results of a bone marrow aspiration along with the results from biopsy specimens of the brachial skin and a cervical lymph node. The expression of retinoic acid-inducible gene-I (RIG-I) in the skin epidermal basal layer as well as in a cervical lymph node was revealed through immunohistochemistry. He successfully entered remission through treatment with prednisolone. This findings of this case indicate that when SS with KD presents as HPS, it may suggest an association with an RIG-I-related innate immunity.
Keywords: Hemophagocytic syndrome / Kikuchi's disease / Retinoic acid-inducible gene-I / Sweet's syndrome
URI: http://hdl.handle.net/10069/33883
ISSN: 09182918
DOI: 10.2169/internalmedicine.52.9542
Rights: © 2013 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33883

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