DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Graduate School of Biomedical Sciences > Articles in academic journal >

Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population


File Description SizeFormat
PLoS8_71382.pdf107.46 kBAdobe PDFView/Open

Title: Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population
Authors: Migita, Kiyoshi / Nakamura, Minoru / Abiru, Seigo / Jiuchi, Yuka / Nagaoka, Shinya / Komori, Atsumasa / Hashimoto, Satoru / Bekki, Shigemune / Yamasaki, Kazumi / Komatsu, Tatsuji / Shimada, Masaaki / Kouno, Hiroshi / Hijioka, Taizo / Kohjima, Motoyuki / Nakamuta, Makoto / Kato, Michio / Yoshizawa, Kaname / Ohta, Hajime / Nakamura, Yoko / Takezaki, Eiichi / Nishimura, Hideo / Sato, Takeaki / Ario, Keisuke / Hirashima, Noboru / Oohara, Yukio / Naganuma, Atsushi / Muro, Toyokichi / Sakai, Hironori / Mita, Eiji / Sugi, Kazuhiro / Yamashita, Haruhiro / Makita, Fujio / Yatsuhashi, Hiroshi / Ishibashi, Hiromi / Yasunami, Michio
Issue Date: 22-Aug-2013
Publisher: Public Library of Science
Citation: PLoS ONE, 8(8), e71382; 2013
Abstract: Background/Aims:Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study.Methodology/Principal Findings:Genomic DNA from 460 individuals of Japanese origin including 230 patients with type-1 autoimmune hepatitis and 230 healthy controls was analyzed for two single nucleotide polymorphisms in the STAT4 gene (rs7574865, rs7582694). The STAT4 rs7574865T allele conferred risk for type-1 autoimmune hepatitis (OR = 1.61, 95% CI = 1.23-2.11; P = 0.001), and patients without accompanying autoimmune diseases exhibited an association with the rs7574865T allele (OR = 1.50, 95%CI = 1.13-1.99; P = 0.005). Detailed genotype-phenotype analysis of type-1 autoimmune hepatitis patients with (n = 44) or without liver cirrhosis (n = 186) demonstrated that rs7574865 was not associated with the development of liver cirrhosis and phenotype (biochemical data and the presence of auto-antibodies).Conclusions/Significance:This is the first study to show a positive association between a STAT4 polymorphism and type-1 autoimmune hepatitis, suggesting that autoimmune hepatitis shares a gene commonly associated with risk for other autoimmune diseases.
URI: http://hdl.handle.net/10069/33889
DOI: 10.1371/journal.pone.0071382
Rights: © 2013 Migita et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33889

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace