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Diffuse Alveolar Hemorrhage in a Patient with Ankylosing Spondylitis

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Title: Diffuse Alveolar Hemorrhage in a Patient with Ankylosing Spondylitis
Authors: Hara, Shintaro / Sakamoto, Noriho / Ishimatsu, Yuji / Kakugawa, Tomoyuki / Shimada, Midori / Kohno, Shigeru
Issue Date: 1-Sep-2013
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 52(17), pp.1963-1966; 2013
Abstract: Ankylosing spondylitis (AS) primarily affects the spine and axial skeleton. Various pulmonary manifestations have been reported; however, diffuse alveolar hemorrhage (DAH) has not been previously described in a patient with AS. A 49-year-old man with longstanding AS visited our hospital complaining of progressive dyspnea and hemoptysis. DAH was diagnosed based on the findings of chest computed tomography and bronchoscopy. No positive findings suggested any cause of DAH other than weakly positive results for perinuclear antineutrophil cytoplasmic antibodies on indirect immunofluorescence. Following the administration of steroid and plasmapheresis therapy, the patient's symptoms and chest radiographic findings improved. Further clinical case reports and investigations are needed to clarify whether DAH represents a possible pulmonary manifestation of AS.
Keywords: Antineutrophil cytoplasmic antibodies / Diffuse alveolar hemorrhage / Plasmapheresis / Pulmonary manifestations of ankylosing spondylitis
URI: http://hdl.handle.net/10069/33907
ISSN: 09182918
DOI: 10.2169/internalmedicine.52.0258
Rights: © 2013 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33907

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