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Usefulness of near-infrared spectroscopy to detect brain dysfunction in children with autism spectrum disorder when inferring the mental state of others


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Title: Usefulness of near-infrared spectroscopy to detect brain dysfunction in children with autism spectrum disorder when inferring the mental state of others
Authors: Iwanaga, Ryoichiro / Tanaka, Goro / Nakane, Hideyuki / Honda, Sumihisa / Imamura, Akira / Ozawa, Hiroki
Issue Date: May-2013
Publisher: 日本精神神経学会 / Japanese Society of Psychiatry and Neurology
Citation: Psychiatry and Clinical Neurosciences, 67(4), pp.203-209; 2013
Abstract: Aims The purpose of this study was to examine the usefulness of near-infrared spectroscopy (NIRS) for identifying abnormalities in prefrontal brain activity in children with autism spectrum disorders (ASD) as they inferred the mental states of others. Methods The subjects were 16 children with ASD aged between 8 and 14 years and 16 age-matched healthy control children. Oxygenated hemoglobin concentration was measured in the subject's prefrontal brain region on NIRS during tasks expressing a person's mental state (MS task) and expressing an object's characteristics (OC task). Results There was a significant main effect of group (ASD vs control), with the control group having more activity than the ASD group. But there was no significant main effect of task (MS task vs OC task) or hemisphere (right vs left). Significant interactions of task and group were found, with the control group showing more activity than the ASD group during the MS task relative to the OC task. Conclusions NIRS showed that there was lower activity in the prefrontal brain area when children with ASD performed MS tasks. Therefore, clinicians might be able to use NIRS and these tasks for conveniently detecting brain dysfunction in children with ASD related to inferring mental states, in the clinical setting.
Keywords: autism spectrum disorders / child / near-infrared spectroscopy / prefrontal cortex / theory of mind
URI: http://hdl.handle.net/10069/33916
ISSN: 13231316
DOI: 10.1111/pcn.12052
Rights: © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33916

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