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In Vivo Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection


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Title: In Vivo Efficacy of Daptomycin against Methicillin-Resistant Staphylococcus aureus in a Mouse Model of Hematogenous Pulmonary Infection
Authors: Harada, Yosuke / Yanagihara, Katsunori / Yamada, Koichi / Migiyama, Yohei / Nagaoka, Kentaro / Morinaga, Yoshitomo / Nakamura, Shigeki / Imamura, Yoshifumi / Hasegawa, Hiroo / Miyazaki, Taiga / Izumikawa, Koichi / Kakeya, Hiroshi / Kohno, Shigeru
Issue Date: Jun-2013
Publisher: American Society for Microbiology
Citation: Antimicrobial Agents and Chemotherapy, 57(6), pp.2841-2844; 2013
Abstract: Daptomycin is inactivated by pulmonary surfactant, but its effectiveness in hematogenous pulmonary infection has been poorly studied. The potential therapeutic application was evaluated in a methicillin-resistant Staphylococcus aureus (MRSA) hematogenous pulmonary infection mouse model. Compared with control results, daptomycin improved survival (P<0.001) and decreased the number of abscesses and bacteria in the lungs (P<0.01). Daptomycin may be an effective therapeutic option for MRSA hematogenous pulmonary infection.
Keywords: daptomycin / methicillin-resistant Staphylococcus aureus / hematogenous / pulmonary infection
URI: http://hdl.handle.net/10069/33918
ISSN: 00664804
DOI: 10.1128/AAC.02331-12
Rights: © 2013, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33918

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