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Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions : Assessment by Optical Coherence Tomography and Intravascular Ultrasound


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Title: Elevated Levels of Systemic Pentraxin 3 Are Associated With Thin-Cap Fibroatheroma in Coronary Culprit Lesions : Assessment by Optical Coherence Tomography and Intravascular Ultrasound
Authors: Koga, Seiji / Ikeda, Satoshi / Yoshida, Takeo / Nakata, Tomoo / Takeno, Masayoshi / Masuda, Nobuhito / Koide, Yuji / Kawano, Hiroaki / Maemura, Koji
Issue Date: Sep-2013
Publisher: Elsevier Inc.
Citation: JACC: Cardiovascular Interventions, 6(9), pp.945-954; 2013
Abstract: Objectives This study sought to determine whether systemic levels of pentraxin 3 (PTX3), a novel inflammatory marker, are associated with thin-cap fibroatheroma (TCFA). Background Biomarkers predicting the presence of TCFA in vivo have not been established. Methods We evaluated 75 patients (stable angina pectoris, n = 47; acute coronary syndrome, n = 28) with de novo culprit lesions who were examined by optical coherence tomography and intravascular ultrasound. We defined TCFA as lipid-rich plaque with a fibrous cap <65 μm thick. Systemic levels of PTX3 were compared between patients with and without TCFA. Results Thirty-eight and 37 patients with and without TCFA, respectively, were identified. Levels of PTX3 were significantly higher in patients with than in those without TCFA (p < 0.001) and correlated inversely with fibrous cap thickness (r = -0.71, p = 0.001) and positively with the remodeling index (r = 0.25, p = 0.037). Multivariate logistic regression analysis showed that a higher PTX3 level was the most powerful predictor of TCFA (odds ratio: 3.26, 95% confidence interval: 1.75 to 6.05, p < 0.001). Receiver-operating characteristic curve analysis showed that >3.24 ng/ml of PTX3 could predict TCFA with 84% sensitivity and 86% specificity. Conclusions Higher levels of systemic PTX3 are associated with TCFA. Systemic PTX3 levels comprise a useful inflammatory marker that reflects coronary plaque vulnerability.
Keywords: optical coherence tomography / pentraxin 3 / thin-cap fibroatheroma / vulnerable plaque
URI: http://hdl.handle.net/10069/33936
ISSN: 19368798
DOI: 10.1016/j.jcin.2013.04.024
Rights: © 2013 by the American College of Cardiology Foundation. / NOTICE: this is the author’s version of a work that was accepted for publication in JACC: Cardiovascular Interventions. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in JACC: Cardiovascular Interventions, 6, 9(2013)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33936

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