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Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands Study


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Title: Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands Study
Authors: Shimizu, Yuji / Nakazato, Mio / Sekita, Takaharu / Kadota, Koichiro / Yamasaki, Hironori / Takamura, Noboru / Aoyagi, Kiyoshi / Maeda, Takahiro
Issue Date: Jun-2013
Publisher: Elsevier Ireland Ltd
Citation: Atherosclerosis, 228(2), pp.491-495; 2013
Abstract: Objective: Although many studies have reported that elevated serum triglycerides to high-density lipoprotein cholesterol (TG-HDL) ratios constitute a risk for insulin resistance and increased arterial stiffness, no study has clarified as yet the association, in terms of the TG-HDL ratio, between diabetes and increased arterial stiffness evaluated by means of carotid intima-media thickness (CIMT) and cardio-ankle vascular index (CAVI). To investigate this association, we conducted a cross-sectional study of 1344 Japanese men aged 36-79 years undergoing a general health check. Methods: We investigated the associations between atherosclerosis/arterial stiffness, evaluated by means of CIMT and CAVI, and diabetes for all subjects, who were divided into tertiles according to TG-HDL levels. Diabetes was defined as HbA1c (NGSP) ≥6.5%, and/or initiation of glucose-lowering medication or insulin therapy. Results: Of the 130 diabetes patients identified in the cohort, 56 patients had high TG-HDL (high TG-HDL diabetes) and 43 had low TG-HDL (low TG-HDL diabetes). We found that only diabetic patients with highTG-HDL were at a significant risk for atherosclerosis (diagnosed as CIMT≥1.1mm) and increased arterial stiffness (diagnosed as CAVI≥8.0). The multivariable-adjusted odds ratios and 95% confidence intervals ofatherosclerosis and increased arterial stiffness for diabetes were 2.67 (95%CI: 1.35-5.28) and 2.36 (95%CI:1.01-5.50), for total TG-HDL diabetes 2.57 (95%CI: 1.32-5.02) and 3.56 (95%CI: 1.50-8.46) for high TG-HDL diabetes, and 1.17 (95%CI: 0.52-2.63) and 0.80 (95%CI: 0.33-1.90) for low TG-HDL diabetes, respectively. Conclusion: Diabetes, especially high TG-HDL diabetes, constitutes a significant risk for increased arterial stiffness and atherosclerosis.
Keywords: BMI / Cross-sectional study / Diabetes / Risk / TG-HDL
URI: http://hdl.handle.net/10069/33937
ISSN: 00219150
DOI: 10.1016/j.atherosclerosis.2013.03.021
Rights: © 2013 Elsevier Ireland Ltd. / NOTICE: this is the author’s version of a work that was accepted for publication in Atherosclerosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis, 228, 2(2013)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33937

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