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Analysis of Intratumor Heterogeneity of EGFR Mutations in Mixed Type Lung Adenocarcinoma

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Title: Analysis of Intratumor Heterogeneity of EGFR Mutations in Mixed Type Lung Adenocarcinoma
Authors: Tomonaga, Nanae / Nakamura, Yoichi / Yamaguchi, Hiroyuki / Ikeda, Takaya / Mizoguchi, Kosuke / Motoshima, Kohei / Doi, Seiji / Nakatomi, Katsumi / Iida, Tetsuya / Hayashi, Tomayoshi / Nagayasu, Takeshi / Tsukamoto, Kazuhiro / Kohno, Shigeru
Issue Date: Sep-2013
Publisher: Elsevier
Citation: Clinical Lung Cancer, 14(5), pp.521-526; 2013
Abstract: Background: Epidermal growth factor receptor mutations are predictive of the success of EGFR tyrosine kinase inhibitor treatment in patients with advanced non-small-cell lung cancer. As with other solid tumors, lung cancer is thought to be the result of an accumulation of genetic alterations after exposure to carcinogens. The aim of the present study was to clarify the relationship between multistep carcinogenesis and the accumulation of EGFR mutations. Patients and Methods: The intratumor heterogeneity of EGFR mutations was analyzed in 38 patients with resected mixed-type lung adenocarcinoma according to histological patterns, and the clinical features of the patients harboring intratumor heterogeneity of EGFR mutations were evaluated. Results: Intratumor heterogeneity of EGFR mutations was detected in 9 of 38 tumors. EGFR mutations were more common in the bronchioloalveolar (lepidic) carcinoma pattern than in the papillary and acinar patterns, although this difference was not significant. However, there was a significant correlation between intratumor heterogeneity of EGFR mutations and smoking history (P <.043). Conclusion: Intratumor heterogeneity of EGFR mutations correlates with the distribution of histological subtype in mixed type adenocarcinoma and is associated with smoking history.
Keywords: EGFR mutations / Heterogeneity / Mixed type adenocarcinoma / Non-small-cell lung cancer / Smoking
URI: http://hdl.handle.net/10069/33941
ISSN: 15257304
DOI: 10.1016/j.cllc.2013.04.005
Rights: © 2013 Elsevier Inc. All rights reserved. / NOTICE: this is the author’s version of a work that was accepted for publication in Clinical Lung Cancer. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Clinical Lung Cancer, 14, 5(2013)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33941

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