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Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy


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Title: Cyclophosphamide-induced Cardiotoxicity with a Prolonged Clinical Course Diagnosed on an Endomyocardial Biopsy
Authors: Kusumoto, Saburo / Kawano, Hiroaki / Hayashi, Tomayoshi / Satoh, Osami / Yonekura, Tsuyoshi / Eguchi, Masamichi / Takeno, Masayoshi / Tsuneto, Akira / Koide, Yuji / Jo, Tatsuro / Maemura, Koji
Issue Date: 15-Oct-2013
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 52(20), pp.2311-2315; 2013
Abstract: A 31-year-old woman with primary mediastinal large B-cell lymphoma refractory to conventional chemotherapy was treated with high-dose chemotherapy containing cyclophosphamide (CY). Subsequently, she was treated with auto peripheral blood stem cell transplantation. Although a complete remission was obtained, heart failure developed two months later. Echocardiography showed an impaired systolic function with peri-cardial effusion. A biopsy of the endomyocardial region from the left ventricle demonstrated spotty myocar-dial hemorrhage and myocardial fibrosis with disruption and aggregation of mitochondrial cristae. Based on these findings, CY-induced cardiotoxicity was diagnosed. The patient was treated with conventional therapy for heart failure, which required approximately one year to improve her condition.
Keywords: Cardiotoxicity / Chemotherapy / Heart failure
URI: http://hdl.handle.net/10069/33973
ISSN: 09182918
DOI: 10.2169/internalmedicine.52.0347
Rights: © 2013 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33973

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