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Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism?

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Title: Can the use of intraoperative intact parathyroid hormone monitoring be abandoned in patients with hyperparathyroidism?
Authors: Sakimura, Chika / Minami, Shigeki / Hayashida, Naomi / Uga, Tatsuya / Inokuchi, Naoko / Eguchi, Susumu
Issue Date: Oct-2013
Publisher: Elsevier Inc.
Citation: The American Journal of Surgery, 206(4), pp.574-577; 2013
Abstract: Background Ultrasound (US) and technetium-99m sestamibi scintigraphy (MIBI) are used to determine the localization of abnormal glands in cases of primary hyperparathyroidism (PHPT). Intraoperative intact parathyroid hormone (iPTH) monitoring is a reliable examination used to cure PHPT. The aim was to assess the necessity of intraoperative iPTH monitoring. Methods Sixty patients were examined using preoperative MIBI and US. iPTH was measured at 3 time points: (1) at the start of surgery; (2) 10 minutes after gland resection; and (3) more than 60 minutes after surgery. We defined a decreased iPTH level as an iPTH measured 10 minutes after resection that was less than 50% of the preoperative level. Results The iPTH of 55 patients with concordant lesions decreased to within the normal range more than 60 minutes after surgery. Conclusions It is not necessary to monitor intraoperative iPTH when single concordant lesions are preoperatively identified on both MIBI and US.
Keywords: Intraoperative intact parathyroid hormone monitoring / Primary hyperparathyroidism / Technetium-99m sestamibi scintigraphy / Ultrasound
URI: http://hdl.handle.net/10069/33987
ISSN: 00029610
DOI: 10.1016/j.amjsurg.2013.01.043
Rights: © 2013 Elsevier Inc. All rights reserved. / NOTICE: this is the author’s version of a work that was accepted for publication in The American Journal of Surgery. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in The American Journal of Surgery, 206, 4(2013)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33987

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