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Association of periodontitis with carotid artery intima–media thickness and arterial stiffness in community-dwelling people in Japan: The Nagasaki Islands study


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Title: Association of periodontitis with carotid artery intima–media thickness and arterial stiffness in community-dwelling people in Japan: The Nagasaki Islands study
Authors: Hayashida, Hideaki / Saito, Toshiyuki / Kawasaki, Koji / Kitamura, Masayasu / Furugen, Reiko / Iwasaki, Takahiro / Hayashida, Yoshiko / Nakazato, Mio / Sekita, Takaharu / Takamura, Noboru / Maeda, Takahiro
Issue Date: Jul-2013
Publisher: Elsevier Ireland Ltd
Citation: Atherosclerosis, 229(1), pp.186-191; 2013
Abstract: Objective: Recent studies have suggested an association between periodontitis and atherosclerosis; however, the relationship between periodontal status and arterial alterations should be clarified. The purpose of this study was to examine associations between periodontal status and carotid intima-media thickness (cIMT) and arterial stiffness using the cardio-ankle vascular index (CAVI) in community dwellers. Methods: A community-based cross-sectional study of 1053 subjects ≥40 years with 10 teeth or more was conducted in Goto, Japan from 2008 to 2010. Results: In a multiple linear regression analysis adjusted for age, sex, number of present teeth, and other confounders, each 1-mm increase in mean periodontal pocket depth corresponded to a 0.02-mm increase in maximal cIMT (. β=0.018; P=0.049) and also to a 0.1 increase in mean CAVI (. β=0.133; P=0.040). In addition, each 1-mm increase in the mean periodontal attachment loss corresponded to a 0.01-mm increase in maximal cIMT (. β=0.013; P=0.040). A multiple logistic regression analysis revealed that each 1-mm increase in mean periodontal pocket depth was associated with an increased risk of a maximal cIMT >1mm (adjusted odds ratio [OR], 1.430; 95% confidence interval [CI], 1.067-1.918; P=0.017) and mean CAVI of ≥8 (OR, 1.323; 95% CI, 1.003-1.743; P=0.047). Furthermore, each 1-mm increase in mean periodontal attachment loss was associated with an increased risk of a maximal cIMT >1mm (OR, 1.251; 95% CI, 1.032-1.516; P=0.022). Conclusion: A linear, dose-dependent relationship was found between periodontal pocket depth, cIMT, and arterial stiffness.
Keywords: Cardio-ankle vascular index / Carotid intima-media thickness / Epidemiology / Periodontitis
URI: http://hdl.handle.net/10069/33988
ISSN: 00219150
DOI: 10.1016/j.atherosclerosis.2013.04.002
Rights: © 2013 Elsevier Ireland Ltd. / NOTICE: this is the author’s version of a work that was accepted for publication in Atherosclerosis. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Atherosclerosis, 229, 1(2013)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/33988

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