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Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis


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Title: Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis
Authors: Kakugawa, Tomoyuki / Tomimura, Saori / Hayashi, Tomayoshi / Sakamoto, Noriho / Ishimatsu, Yuji / Mukae, Hiroshi / Kohno, Shigeru
Issue Date: Oct-2013
Publisher: S. Karger AG
Citation: Respiration, 86(4), pp.347-351; 2013
Abstract: A 76-year-old man with interstitial lung disease was admitted to our institution after developing persistent dyspnea upon effort. He also had a relapse of bullous eruptions on the skin of the trunk and extremities, previously diagnosed as vesicular pemphigoid. Direct immunofluorescence of a skin biopsy specimen using fluorescence microscopy showed the linear deposition of immunglobulin A (IgA), IgG and C3 along the basement membrane. These findings indicated a definitive diagnosis of linear IgA/IgG bullous dermatosis. Chest computed tomography, bronchoalveolar lavage and transbronchial lung biopsy findings suggested nonspecific interstitial pneumonia. Direct immunofluorescence of the lung biopsy specimens using fluorescence microscopy also showed a deposition of IgA, IgG and C3 along the epithelial cell membranes and basement membranes of the bronchioles and alveoli. Lung disorders associated with linear IgA/IgG bullous dermatosis are extremely rare and, to our knowledge, this is the first report of such a case of interstitial pneumonia.
Description: 著者版でのFigure 1は非公開。出版社版はDOIリンクを参照のこと。
Keywords: Interstitial pneumonia / Linear immunoglobulin A/immunoglobulin G bullous dermatosis / Lung disorders
URI: http://hdl.handle.net/10069/34044
ISSN: 00257931
DOI: 10.1159/000351427
Rights: © 2013 S. Karger AG, Basel.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34044

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