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Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

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タイトル: Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma
著者: Kimura, Ryuichiro / Rokkaku, Takayoshi / Takeda, Shinji / Senba, Masachika / Mori, Naoki
発行日: 2013年10月30日
出版者: Multidisciplinary Digital Publishing Institute (MDPI)
引用: Marine Drugs, 11(11), pp.4267-4278; 2013
抄録: In this study, we analyzed the size-dependent bioactivities of fucoidan by comparing the cytotoxic effects of native fucoidan and fucoidan lipid nanoparticles on osteosarcoma in vitro and in vivo. In vitro experiments indicated that nanoparticle fucoidan induced apoptosis of an osteosarcoma cell line more efficiently than native fucoidan. The more potent effects of nanoparticle fucoidan, relative to native fucoidan, were confirmed in vivo using a xenograft osteosarcoma model. Caco-2 cell transport studies showed that permeation of nanoparticle fucoidan was higher than native fucoidan. The higher bioactivity and superior bioavailability of nanoparticle fucoidan could potentially be utilized to develop novel therapies for osteosarcoma.
キーワード: Apoptosis / Fucoidan / Lung metastasis / Nanoparticle / Osteosarcoma
URI: http://hdl.handle.net/10069/34054
DOI: 10.3390/md11114267
権利: © 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/34054



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