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Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines


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Title: Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines
Authors: Gichuhi, Paul N. / Kuriyama, Masami / Onomura, Osamu
Issue Date: 2014
Publisher: 日本複素環化学研究所 / Japan Institute of Heterocyclic Chemistry
Citation: HETEROCYCLES, 88(1), pp.331-346; 2014
Abstract: A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been developed. Also, optically active trans-2-allyl-3-fluorinated pyrrolidines have been prepared by utilizing nucleophilic fluorination of hydroxyl group of trans-hydroxy-L-proline and Lewis acid mediated diastereoselective allylation as key steps.
URI: http://hdl.handle.net/10069/34067
ISSN: 03855414
DOI: 10.3987/COM-13-S(S)27
Rights: © 2014 The Japan Institute of Heterocyclic Chemistry
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34067

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