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Significance of Background Coloration in Endoscopic Detection of Early Esophageal Squamous Cell Carcinoma

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Title: Significance of Background Coloration in Endoscopic Detection of Early Esophageal Squamous Cell Carcinoma
Authors: Minami, Hitomi / Isomoto, Hajime / Inoue, Haruhiro / Akazawa, Yuko / Yamaguchi, N. / Ohnita, Ken / Takeshima, Fuminao / Hayashi, Tomayoshi / Nakayama, T. / Nakao, Kazuhiko
Issue Date: Jan-2014
Publisher: S. Karger AG
Citation: Digestion, 89(1), pp.6-11; 2014
Abstract: Endoscopic diagnostics of early squamous cell carcinoma (SCC) in the laryngo-esophageal region have dramatically improved together with development of less invasive endoscopic treatment. It is essential for gastrointestinal endoscopists to detect lesions when they are still endoscopically treatable, especially in this region since surgical approach can still be extremely invasive. Pioneers have found some notable fundamental alterations in early SCC and created several classifications. Inoue [Dig Endosc 2001;13(suppl): 40-41] proposed the intrapapillary capillary (IPCL) classification, which focused on the microvascular change of the mucosal surface. One of the significances of this classification is that it clearly distinguished the lesions that require further pathological evaluation by categorizing the diameter change of the IPCLs. On the other hand, Arima et al. [Esophagus 2005;2:191-197] advocated the alteration of microvessels as well as change of the vascular arrangement in the area. Most recently, the Japan Esophageal Society constructed a new classification uniting these two exemplary classifications as the 'Japanese Classification of Magnifying Endoscopy for Early Squamous Cell Carcinoma'. This classification was intended to be simple and easily applicable in general clinical practice. Brownish color change between the IPCLs has reported to be one of the useful findings in distinguishing early SCC from benign changes such as inflammatory change and low-grade intraepithelial neoplasia. Nevertheless, the exact cause of this phenomenon remains unclear. We recently examined the association of color change with hemoglobin (Hb) in cancer tissue, since NBI exclusively detects the wavelength of Hb in superficial vessels in the gastrointestinal tract. This review article also describes our examination of a distinct finding in esophageal cancer, namely, 'background coloration'.
Keywords: Background coloration / Esophageal cancer / Image-enhanced endoscopy / Magnifying endoscopy / Narrow band imaging / Squamous cell carcinoma
URI: http://hdl.handle.net/10069/34198
ISSN: 00122823
DOI: 10.1159/000356200
Rights: © 2014 S. Karger AG, Basel.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34198

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