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Protective effect of CeO2 nanoparticles on photo-induced oxidative damage of DNA


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Title: Protective effect of CeO2 nanoparticles on photo-induced oxidative damage of DNA
Authors: Fujita, Naoko / Kamada, Kai
Issue Date: 1-Feb-2014
Publisher: 日本セラミックス協会 / The Ceramic Society of Japan
Citation: Journal of the Ceramic Society of Japan, 122(1422), pp.141-145; 2014
Abstract: The present paper demonstrates that inorganic ceria (CeO2) nanoparticles effectively inhibit anomalous oxidative damage of DNA induced by ultraviolet (UV) light irradiation. To utilize the CeO2 nanoparticles for the protection test of DNA, a colloidal solution of monodispersed and crystallized CeO2 nanoparticles is synthesized through a photochemical reaction of Ce(NO3)3 solution, followed by dialysis to remove unreacted electrolytes. Subsequently, the UV light induced oxidative damage of DNA in the presence or absence of CeO2 nanoparticles is evaluated by a quantitative analysis of 8-hydroxy-2-deoxyguanosine (8-OHdG) which is an oxidation product of guanine in base sequences. The 8-OHdG concentration in DNA is increased by the exposure to UV light. On the other hand, the co-presence of CeO2 nanoparticles diminish the formation rate of 8-OHdG. Such favorable effect of CeO2 nanoparticles is due to an excellent annihilation activity of reactive oxygen species (ROS) accounting for the DNA oxidation as well as a UV light absorption ability based on semiconducting nature.
Keywords: Anti-oxidation / Enzyme-mimetic activity / Oxide nanoparticle / Radical annihilation
URI: http://hdl.handle.net/10069/34272
ISSN: 18820743
DOI: 10.2109/jcersj2.122.141
Rights: © 2014 The Ceramic Society of Japan. All rights reserved.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34272

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