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Diagnostic criteria for acute-onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus


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Title: Diagnostic criteria for acute-onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus
Authors: Kawasaki, Eiji / Maruyama, Taro / Imagawa, Akihisa / Awata, Takuya / Ikegami, Hiroshi / Uchigata, Yasuko / Osawa, Haruhiko / Kawabata, Yumiko / Kobayashi, Tetsuro / Shimada, Akira / Shimizu, Ikki / Takahashi, Kazuma / Nagata, Masao / Makino, Hideichi / Hanafusa, Toshiaki
Issue Date: Jan-2014
Publisher: Blackwell Publishing Asia Pty Ltd
Citation: Journal of Diabetes Investigation, 5(1), pp.115-118; 2014
Abstract: Type 1 diabetes is a disease characterized by destruction of pancreatic β-cells, which leads to absolute deficiency of insulin secretion. Depending on the manner of onset and progression, it is classified as fulminant, acute-onset or slowly progressive type 1 diabetes. Here, we propose the diagnostic criteria for acute-onset type 1 diabetes mellitus. Among the patients who develop ketosis or diabetic ketoacidosis within 3 months after the onset of hyperglycemic symptoms and require insulin treatment continuously after the diagnosis of diabetes, those with anti-islet autoantibodies are diagnosed with 'acute-onset type 1 diabetes mellitus (autoimmune)'. In contrast, those whose endogenous insulin secretion is exhausted (fasting serum C-peptide immunoreactivity <0.6 ng/mL) without verifiable anti-islet autoantibodies are diagnosed simply with 'acute-onset type 1 diabetes mellitus'. Patients should be reevaluated after certain periods in case their statuses of anti-islet autoantibodies and/or endogenous insulin secretory capacity are unknown.
Keywords: Criteria / Diagnosis / Type 1 diabetes
URI: http://hdl.handle.net/10069/34274
ISSN: 20401116
DOI: 10.1111/jdi.12119
Rights: © 2013 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and Wiley Publishing Asia Pty Ltd / This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34274

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