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The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT


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Title: The effects of once-weekly teriparatide on hip structure and biomechanical properties assessed by CT
Authors: Ito, Masako / Oishi, R. / Fukunaga, Masao / Sone, T. / Sugimoto, Toshitsugu / Shiraki, M. / Nishizawa, Y. / Nakamura, Toshitaka
Issue Date: Mar-2014
Publisher: Springer London
Citation: Osteoporosis International, 25(3), pp.1163-1172; 2014
Abstract: Once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters and biomechanical parameters at the proximal femur by CT geometry analysis. Introduction: The aim of this study was to evaluate the effects of weekly administration of teriparatide [human PTH (1-34)] on bone geometry, volumetric bone mineral density (vBMD), and parameters of bone strength at the proximal femur which were longitudinally investigated using computed tomography (CT). Methods: The subjects were a subgroup of a recent, randomly assigned, double-blind study (578 subjects) comparing the anti-fracture efficacy of a once-weekly subcutaneous injection of 56.5 μg teriparatide with placebo (TOWER trial). Results: Sixty-six ambulatory postmenopausal women with osteoporosis were enrolled at 15 study sites having multi-detector row CT, and included women injected with teriparatide (n = 29, 74.2 ± 5.1 years) or with placebo (n = 37, 74.8 ± 5.3 years). CT data were obtained at baseline and follow-up scans were performed at 48 and 72 weeks. The data were analyzed to obtain cross-sectional densitometric, geometric, and biomechanical parameters including the section modulus (SM) and buckling ratio (BR) of the femoral neck, inter-trochanter, and femoral shaft. We found that once-weekly teriparatide increased cortical thickness/cross-sectional area (CSA) and total area, and improved biomechanical properties (i.e., decreasing BR) at the femoral neck and shaft. Teriparatide did not change the cortical perimeter. Conclusions: Our longitudinal analysis of proximal femur geometry by CT revealed that once-weekly administration of 56.5 μg teriparatide improved cortical bone parameters at the femoral neck and shaft and also improved biomechanical parameters.
Keywords: Once-weekly injection / Osteoporosis / Proximal femur geometry / Quantitative computed tomography / Teriparatide
URI: http://hdl.handle.net/10069/34289
ISSN: 0937941X
DOI: 10.1007/s00198-013-2596-y
Rights: © The Author(s) 2013. This article is published with open access at Springerlink.com
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34289

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