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Is a fluorescence navigation system with indocyanine green effective enough to detect liver malignancies?

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Title: Is a fluorescence navigation system with indocyanine green effective enough to detect liver malignancies?
Authors: Tanaka, Takayuki / Takatsuki, Mitsuhisa / Hidaka, Masaaki / Hara, Takanobu / Muraoka, Izumi / Soyama, Akihiko / Adachi, Tomohiko / Kuroki, Tamotsu / Eguchi, Susumu
Issue Date: Mar-2014
Publisher: 日本肝胆膵外科学会 / Japanese Society of Hepato-Biliary-Pancreatic Surgery
Citation: Journal of Hepato-Biliary-Pancreatic Sciences, 21(3), pp.199-204; 2014
Abstract: Background Although several reports have shown the efficacy of a fluorescence navigation system (FNS) with indocyanine green (ICG) to detect liver malignancies during hepatectomy, the real accuracy of this procedure is not yet clear. This study aimed to analyze the actual efficacy of ICG-FNS in cirrhotic and non-cirrhotic livers. Methods Ten cirrhotic whole livers explanted from liver transplant recipients and 23 non-cirrhotic livers from patients who underwent hepatectomy for various kinds of liver tumors were investigated with ICG-FNS. All surgical specimens were analyzed macroscopically and pathologically. Results In the patients with a cirrhotic liver, most nodules illuminated by ICG-FNS were diagnosed as regenerative nodules pathologically. The positive predictive value was 5.4%. There was a significant difference in positive predictive value to detect malignant liver tumors between cirrhotic liver and non-cirrhotic liver (5.4% vs 100%, P < 0.0001). In the non-cirrhotic livers, 11 of 33 (32.4%) tumors were not recognized by ICG-FNS through the liver surface before resection. There was a significant difference in the depth from the liver surface to tumor between illuminated nodules and non-illuminated nodules (1.5 mm vs 11.6 mm, P < 0.01). Conclusions It is necessary to know the limitation of ICGFNS when detecting liver malignancies in both cirrhotic and non-cirrhotic livers.
Keywords: Indocyanine green / Liver tumor
URI: http://hdl.handle.net/10069/34391
ISSN: 18686974
DOI: 10.1002/jhbp.17
Rights: © 2013 Japanese Society of Hepato-Biliary-Pancreatic Surgery. / This is the accepted version of the following article: Journal of Hepato-Biliary-Pancreatic Sciences, 21 (3), pp. 199-204;2014, which has been published in final form at http://dx.doi.org/10.1002/jhbp.17
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34391

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