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Anti-glycyl tRNA synthetase antibody associated interstitial lung disease without symptoms of polymyositis/dermatomyositis


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Title: Anti-glycyl tRNA synthetase antibody associated interstitial lung disease without symptoms of polymyositis/dermatomyositis
Authors: Hara, Yuki / Tanaka, Tomonori / Tabata, Kazuhiro / Shiraki, Akira / Hayashi, Kentaro / Kashima, Yukio / Hayashi, Tomayoshi / Fukuoka, Junya
Issue Date: Mar-2014
Publisher: 日本病理学会 / Japanese Society of Pathology
Citation: Pathology International, 64(3), pp.148-150; 2014
Abstract: Anti-Glycyl tRNA synthetase (EJ) autoantibody is a form of eight anti-aminoacyl tRNA synthetase (ARS) antibodies which frequently associate with polymyositis (PM) and dermatomyositis (DM). Interstitial lung disease (ILD) rarely is an only disease among those patients in which patients with anti-EJ antibody are fairly common, however, their pathological features have never been described. Here, we report a case of anti-EJ antibody associated ILD without symptoms of PM/DM. A 56 year-old woman presented rapidly progressing dyspnea. Her radiograph showed ILD and wedge lung biopsy was taken for pathological diagnosis. The biopsy showed cellular and fibrotic ILD best fitting to non-specific interstitial pneumonia along with the features of acute lung injury. The patient was treated with high dose methylprednisolone followed by combination of prednisolone and cyclosporine, which showed good response.
Keywords: anti-EJ antibodies / anti-aminoacyl-tRNA synthetase autoantibodies / acute lung injury / Pathology / pneumonia
URI: http://hdl.handle.net/10069/34395
ISSN: 13205463
Rights: © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd / 利用は著作権の範囲内に限られる / The definitive version is available at www.blackwell-synergy.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34395

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