DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Graduate School of Biomedical Sciences > Articles in academic journal >

Association between Hemoglobin and Diabetes in Relation to the Triglycerides-to-High-Density Lipoprotein Cholesterol (TG-HDL) Ratio in Japanese Individuals: The Nagasaki Islands Study


File Description SizeFormat
IntMed53_837.pdf145.44 kBAdobe PDFView/Open

Title: Association between Hemoglobin and Diabetes in Relation to the Triglycerides-to-High-Density Lipoprotein Cholesterol (TG-HDL) Ratio in Japanese Individuals: The Nagasaki Islands Study
Authors: Shimizu, Yuji / Nakazato, Mio / Sekita, Takaharu / Koyamatsu, Jun / Kadota, Koichiro / Yamasaki, Hironori / Goto, Hisashi / Takamura, Noboru / Aoyagi, Kiyoshi / Maeda, Takahiro
Issue Date: 15-Apr-2014
Publisher: 日本内科学会 / Japanese Society of Internal Medicine
Citation: Internal Medicine, 53(8), pp.837-843; 2014
Abstract: Objective Our previous study reported that categorizing diabetes patients according to the serum triglycerides-to-high-density lipoprotein cholesterol (TG-HDL) ratio is useful for estimating the risk of atherosclerosis, as a high TG-HDL ratio in patients with diabetes constitutes risk factors for atherosclerosis. Another study showed that a high hemoglobin level is associated with the risk of atherosclerosis. However, no previous studies have examined the association between the hemoglobin level and diabetes categorized by the TG-HDL ratio. In order to investigate these associations, we conducted a cross-sectional study of 3,733 (1,299 men and 2,434 women) Japanese participants 30-89 years of age undergoing a general health checkup. Methods We investigated the association between the hemoglobin levels and the incidence of diabetes in all subjects, who were divided into tertiles according to the TG-HDL ratio. Diabetes was defined as an HbA1c (NGSP) level of ≥6.5% and/or the initiation of glucose-lowering or insulin therapy. Results Of the 265 diabetes patients identified in this study, 116 had a high TG-HDL ratio (high TG-HDL diabetes) and 71 had a low TG-HDL ratio (low TG-HDL diabetes). Independent from classical cardiovascular risk factors, the multivariate odds ratio of a 1 SD (standard deviation) increment in hemoglobin (1.30 g/dL for men, 1.16 g/dL for women) was 1.04 (95% confidence intervals (CI): 0.88-1.22) for all patients with diabetes, 1.44 (95%CI: 1.17-1.77) for the patients with high TG-HDL diabetes and 0.67 (95%CI: 0.54-0.83) for the patients with low TG-HDL diabetes. Conclusion The hemoglobin level is positively associated with high TG-HDL diabetes and inversely associated with low TG-HDL diabetes. These findings suggest that measuring the hemoglobin level is clinically relevant for estimating the risk of atherosclerosis in patients with diabetes categorized according to the TGHDL ratio.
Keywords: Cross-sectional study / Diabetes / Hemoglobin / Japanese / TG-HDL
URI: http://hdl.handle.net/10069/34438
ISSN: 09182918
DOI: 10.2169/internalmedicine.53.1423
Rights: © 2014 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34438

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace