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Analysis of the Hepatic Functional Reserve, Portal Hypertension, and Prognosis of Patients With Human Immunodeficiency Virus/Hepatitis C Virus Coinfection Through Contaminated Blood Products in Japan


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Title: Analysis of the Hepatic Functional Reserve, Portal Hypertension, and Prognosis of Patients With Human Immunodeficiency Virus/Hepatitis C Virus Coinfection Through Contaminated Blood Products in Japan
Authors: Eguchi, Susumu / Takatsuki, Mitsuhisa / Soyama, Akihiko / Hidaka, Masaaki / Nakao, Kazuhiko / Shirasaka, Takuma / Yamamoto, Masahiro / Tachikawa, Natsuo / Gatanaga, Hiroyuki / Kugiyama, Yuki / Yatsuhashi, Hiroshi / Ichida, Takafumi / Kokudo, Norihiro
Issue Date: Apr-2014
Publisher: Elsevier USA
Citation: Transplantation Proceedings, 46(3), pp.736-738; 2014
Abstract: Background As the survival of human immunodeficiency virus (HIV)-infected individuals has improved due to the widespread use of antiretroviral therapy, the mortality rate due to hepatitis C virus (HCV)-related liver disease has increased in HIV/HCV-coinfected patients. Aim The aims of this study were to establish the appropriate therapeutic strategy for HIV/HCV-coinfected patients by evaluating the liver function, including the hepatic functional reserve and portal hypertension, and to investigate the prognosis of HIV/HCV-coinfected patients in Japan. Patients and Methods In addition to regular liver function tests, the hepatic functional reserve of 41 patients with HIV/HCV coinfection was evaluated using the indocyanine green retention rate and liver galactosyl serum albumin-scintigraphy. The data for 146 patients with HIV/HCV coinfection through blood products were extracted from 4 major HIV centers in Japan. In addition to liver function tests, the platelet counts (PLT) were evaluated as a marker of portal hypertension. Results In spite of the relatively preserved general liver function test results, approximately 40% of the HIV/HCV-coinfected patients had an impaired hepatic functional reserve. In addition, while the albumin and bilirubin levels were normal, the PLT was <150,000/μL in 17 patients. Compared with HCV mono-infected patients with a PLT <150,000/μL, the survival of HIV/HCV-coinfected patients was shorter (HCV, 5 years, 97%; 10 years, 86% and HIV/HCV, 5 years, 87%; 10 years, 73%; P <.05). Conclusion These results must be taken into account to establish an optimal therapeutic strategy, including the appropriate timing of liver transplantation in HIV/HCV-coinfected patients in Japan.
Keywords: non-cirrhotic portal hypertension / highly active antiretroviral therapy / contaminated blood products / hemophilia / liver transplantation
URI: http://hdl.handle.net/10069/34457
ISSN: 00411345
DOI: 10.1016/j.transproceed.2013.11.126
Rights: © 2014 by Elsevier Inc. All rights reserved. / NOTICE: this is the author’s version of a work that was accepted for publication in Transplantation Proceedings>. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Transplantation Proceedings, 46, 3, (2014)
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34457

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