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Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study

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Title: Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study
Authors: Shimizu, Yuji / Sato, Shimpei / Koyamatsu, Jun / Yamanashi, Hirotomo / Nagayoshi, Mako / Kadota, Koichiro / Tamai, Mami / Arima, Kazuhiko / Yamasaki, Hironori / Kusano, Yosuke / Takamura, Noboru / Maeda, Takahiro
Issue Date: 17-Apr-2014
Publisher: 日本生理人類学会 / Japan Society of Physiological Anthropology
Citation: Journal of Physiological Anthropology, 33(1), 7; 2014
Abstract: Background: Renal impairment is known to be associated with atherosclerosis, which in turn is reported to be positively associated with hemoglobin levels. In addition, renal impairment is known to be associated with a form of anemia known as renal anemia.Methods: To clarify the associations between renal impairment and anemia, we conducted a cross-sectional study of 1,105 60 to 89-year-old men, who were not taking medication for anemia and were undergoing general health check-ups.Results: Compared with non-chronic kidney disease, chronic kidney disease (CKD) with a glomerular filtration rate (GFR) <60 mL/min/1.73 m2 was found to constitute a significant risk of anemia. However, we noted that this risk was lower for mild renal impairment (60 mL/min/1.73 m2 ≤ GFR <90 mL/min/1.73 m2). Compared with the non-CKD reference group, the classical cardiovascular risk factors adjusted odds ratio (OR) for anemia was 1.81 (1.23 to 2.68) and compared with the normal renal function (GFR ≥90 mL/min/1.73 m2) reference group, the ORs for mild renal impairment and CKD were 0.26 (0.15 to 0.47) and 0.60 (0.33 to 1.09).Conclusions: Independent from classical cardiovascular risk factors, CKD, which was identified during general health check-ups, appeared to constitute a significant risk of anemia for older Japanese men. For mild renal impairment, however, this association was a reduced risk of anemia and thus possibly a higher risk of atherosclerosis.
Keywords: Anemia / CKD / GFR / Men / Renal impairments
URI: http://hdl.handle.net/10069/34489
ISSN: 18806805
DOI: 10.1186/1880-6805-33-7
Rights: © 2014 Shimizu et al.; licensee BioMed Central Ltd. / This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/34489

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